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Monoclonal Antibodies

I am immunosuppressed as a result of my blood cancer type, and from reading information on this site, I am likely to have received little or no antibody protection benefit from my 2 previous vaccinations.
These circumstances have been addressed on this site, and the conclusion was that Monoclonal antibody vaccinations now under test would give far more reliable protection in a booster jab.
The government is now proposing to give sufferers like myself a booster jab of the same type of vaccine that has already been proved not to produce antibodies in cases like mine.

Not only is this likely to be useless, but it is stated that another booster cannot be administered within the following 6 months. So, if monoclonal antibody vaccinations are available by the end of this year as hoped, I won’t be able to have it.

There is never a mention of the this monoclonal development by the government, I wonder why, could it possibly be they are not keen on us knowing of it’s potential?

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Surely a monoclonal antibody treatment cannot be called a booster??

It is a first-time injection or infusion of antibodies.

The Government might add that it is likely to be very expensive. We might have to end up by clubbing together and getting Roche to sell some to us!! Otherwise, we will have to shield for a very long time.

Jumbo4

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Hi @MANS643 a great big welcome, yes, I think you have voiced what so many of us are thinking.
Personally, not medically trained, I think I agree with @jumbo4 that monoclonal antibody treatment cannot be called a booster.
However perhaps a reliable antibody test is required whether we have had 2 or 3 vaccinations before we know if monoclonal antibody treatment is required.
I am as confused as everyone else.

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Hello Mans643 welcome. Yes it is all of a minefield isn’t it! I think the idea of the third vaccine is the belief a third one may be effective to “kick start” compromised immune systems that have struggled to respond on two doses, thought to be effective particularly if it is a mRNA based vaccine like Pfizer. The monoclonal antibody is as others said an alternative and different to the vaccines in administering manufactured antibodies direct into the blood system with the benefit our compromised immune systems haven’t got to be asked to produce anything. I believe the Astra Zeneca treatment of this is now up for approval, how long that may take who knows, and yes I do believe it is expensive treatment.
It is a confusing time, we want the help out there but it is difficult to get direction as there are so many ifs on what’s available, to who and when!! At least we all have empathy with each other and usually good medical teams we deal with as well as all the excellent help from BCUK.

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It’s a very complicated issue and not an exact science but I can fully understand the anxiety. I’m a patient participant in the Rudy study at Oxford University and provide them with blood samples. They tell me what the outcome of their tests is and suggested that I’ve had quite good protection on both an antibody an t-cell basis.

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@Franko that’s good news and you know about your antibodies and t-cell responses too.

Whether the Monoclonal treatment is called a “booster” or not, would we be able to have it if we have had the proposed 3rd vaccination?

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Hi @MANS643 another good question and dilemma which we need to know before we go ahead with a 3rd vaccine, if we are offered it!!!

Having just watched the televised briefing on the booster jab plans and the Health Secretary’s House of Commons statement, I am, predictably, none the wiser regarding Monoclonal possibilities.

My only option is to take the 3rd or booster vaccination, whichever you choose to call it, and hope I get some protection. Of course I will never know if I have, as there are no tests available.

Keep smiling

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Oh I’m smiling @MANS643 you word it so well

I like Franko am part Rudy study at Oxford University and provide them with blood samples. And again like Franko They tell me what the outcome of their tests is and suggested that I’ve had quite good protection on both an antibody an t-cell basis.

I have MM and I am starting my Stem Cell Transplant Monday Oct 20 which will kill the anti bodies etc. But I will be asking for the first vaccine before I leave hospital.

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Hi @AndyMeer great to hear from you again and that you are on the Oxford Rudy study.
I am glad that you have a date for your stem cell transplant. Scary times. There is a post on this forum here for people undertaking stem cell transplants where people are sharing their experiences.
Please let us know how you get on.

Hi @MANS643 and welcome to the forum. We totally understand the confusion and lack of information around the 3rd vaccine, booster vaccine and monoclonal antibody treatment.

The UK government has announced that severely immunosuppressed adults and children aged 12 and over will get a third dose of the covid vaccine this autumn.

The third dose is for people who had weakened immune systems at the time of their first or second vaccination, and who might not have produced enough antibodies from the vaccine. The third dose is part of the primary treatment and aims to increase the level of immunity gained from the vaccine. Please note that this is different from the booster jab, which other vulnerable groups are being offered, and which aims to extend the length of time the protection lasts. People who get a third dose of the vaccine this autumn may also get a booster vaccination in around six months’ time, but this hasn’t been confirmed.

The group offered a third dose includes people who:
• are having treatment for blood cancer, or are in remission after having treatment in the previous 12 months
• had either an allogeneic or autologous stem cell transplant in the previous 24 months
• had a stem cell transplant more than 24 months before, but had ongoing immunity issues
• are on watch and wait (active monitoring) for any type of blood cancer.

We’ve been assured that there is room for clinical judgement on who gets the third dose. So groups that aren’t specifically mentioned in the guidance but are considered to be at high risk can get a third dose.

The government has also announced that a vaccine booster programme is starting in September 2021 across the UK. This is a separate programme from the third dose for severely immunosuppressed people (see above).

The booster programme aims to extend the protection that people with healthy immune systems have already gained from their first and second doses. The same priority groups that were used for the vaccine roll-out will be used for the booster programme, with added flexibility on timing to make sure that people get their booster six months after their second dose.

The groups offered a booster include:
• Anyone ‘clinically extremely vulnerable’ or ‘clinically vulnerable’ who doesn’t have immunosuppression (because anyone with immunosuppression should be given a third primary dose instead - see above).
• Household contacts and unpaid carers (aged 16 or over) of people with blood cancer (household contacts and unpaid carers aged 12-15 won’t be offered a booster yet, if they’ve only had their second dose recently).
• those living in residential care homes for older adults
• all adults aged 50 years or over
• frontline health and social care workers

It is advised that the third primary dose should ideally be given at least 8 weeks after the second dose – although special attention should be paid to current or planned immunosuppressive therapies. The booster will be offered no earlier than 6 months after completion of the primary vaccine course.

For more information about the third dose and/or the booster, visit our webpage https://bloodcancer.org.uk/support-for-you/coronavirus-covid-19/covid-vaccine-blood-cancer/how-to-get-vaccine/

With reference to Monoclonal antibody treatment from AstraZeneca (PROVENT trial). AstraZeneca have said they will now prepare to submit their trial results to the regulators (MHRA in the UK) to seek approval to make this drug available to people. If the MHRA approves its use, the government and health departments will need to plan how to roll out this medicine to people in the UK. We haven’t got the details about how this will be administered and the gap from last dose of vaccine to Monoclonal antibody treatment.

We will monitor this closely and update our information as soon as we hear more, but this is positive news for people with blood cancer.

We hope this is helpful to you, but please do remember, our Support Services Team are always here if there’s anything you’d like to talk through further: Blood cancer information and support by phone and email | Blood Cancer UK

Best Wishes
Bav

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I would rather just have the antibody injection even if I had to try and pay for it.

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I would be willing pay for anything that will give me protection. I have already paid for 2 antibody tests which apparently are not available through the NHS. The first test showed I had no antibodies at all. The second showed I had between 0.8 and 5 which is very weak and not enough to give protection. My GP is less than helpful and couldn’t answer any of my questions. He actually said I could get run over by a bus when I asked what is likely to happen if I catch covid and should I be going the places I have been to recently.

He has given me false information about the flu vaccine. I was supposed to have one today but I cancelled it because he said if I had it I wouldn’t be able to have the vovid vaccine for 7 days. He couldn’t tell me when I would be able to have the covid jab but I wasn’t prepared to risk not being able to have it ASAP. I told him the government are are impending having both together but he said the latest information he had was to leave a 7 day gap. I am seeing my hospital consultant on Tuesday so hopefully I will get better information from him.

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Hi @ilivesunshine I had my flu jab yesterday because I was told I won’t be able to have the 3rd Vaccine till 6 mths after the 2nd which will be 17/10/21.
Please do let us know what your consultant says on Tuesday.
I think everyone is floundering on this one, health professional or not.

@MANS643 , @jumbo4 all really good questions - I hope my colleague Bav’s post below has cleared things up in terms of what we know so far about third jabs, booster jabs and the Monoclonal antibody therapy but please be assured we are monitoring the developments around these and will be sure to keep reviewing and updating our information. We have updated our page here around what we know so far around the antibody treatments used to prevent and treat Covid - Antibody treatments for people with blood cancer | Blood Cancer UK

Information on third vaccine doses and booster doses can be found here - How to get a covid vaccine if you have blood cancer | Blood Cancer UK

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@AndyMeer wishing you all the very best over the next month - if there’s any general info you need around stem cell transplants please don’t hesitate to get in touch. You might also find this thread useful to be part of - Awaiting or considering or had a stem cell transplant, a place to share here - Going through treatment - Blood Cancer UK Forum Take care and all the best, Alice

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Hi @Erica hope you’re well :slight_smile: just wanted to respond to your comment about the 3rd vaccine.
As it explains here it is advised that the third primary dose should ideally be given at least 8 weeks after the second dose – although special attention should be paid to current or planned immunosuppressive therapies.
The booster will be offered no earlier than 6 months after completion of the primary vaccine course.

If you have blood cancer, it’s important to get your third dose, rather than the booster. This is because for some types of vaccine (like Moderna), the third dose is a full dose but the booster dose is only a half dose. It’s also important because it gives you the chance to have three primary doses rather than two, and possibly a fourth dose (booster) in the future as well (although we are waiting for confirmation on future booster doses for this group). Having a third dose aims to increase your antibody response to the vaccine.

As always though Erica and as you know, this is general information so do speak to your consultant or GP if you haven’t already as it’s important you get the right advice for your individual circumstances.

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Thanks @Alice_BloodCancerUK and Blood Cancer UK for giving us reliable information.
My surgery were actually just getting the NHS information starting to come through when I had my flu jab.
Thanks again @Alice_BloodCancerUK

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