Secondary Hypoglobulinemia and MGUS

Living with and after blood cancer
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Hi,

It has just come to light that my total igG has dipped below normal on the last consecutive readings and that there has been a downward trend over the years.

I wondered if anyone else with Monoclonal gammopathy of unknown significance ('MGUS') has experienced this.

I have igM Monoclonal gammopathy of unknown significance ('MGUS') and my paraprotein is still too low to quantify.

Helen

Helen

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Hello again @helenfwallace, sorry to read about that dip in total igG, sounds like you keep a close eye on what your cells are doing. I do likewise with my own, although I live with Polycythaemia vera ('PV') rather than Monoclonal gammopathy of unknown significance ('MGUS').

That’s about the extent of my understanding of Monoclonal gammopathy of unknown significance ('MGUS') though, so I had a look around the forum to see if others have shared similar to you, hope you don’t mind.

Here’s a recent thread with some lovely forum members you might like to reach out to, talking here about changing blood test results: MGUS with rising Free Lambda and falling kappa lambda ratio

Another thread mentioning igG directly: I have recently been diagnosed with MGUS

Hope that helps a little @helenfwallace.

Don’t forget, medical queries can always be asked of the specialist Blood Cancer UK nurses, just call them free on 0808 2080 888.

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Hi @helenfwallace,

Thank you for sharing this - may I ask what your team has said about the Secondary Hypoglobulinemia?

I can see that lovely Duncan, one of our Forum Support Volunteers, has linked a couple of threads above where others have talked through changing test results, so hopefully some of that feels familiar. On the clinical side, I’m going to share your thread with our Blood Cancer UK nurses, and they can see if thery have anything to add. If not, I suspect that your own team will be best placed to offer you advice anyway.

You might also find our page on MGUS diagnosis and monitoring useful background on what these blood tests are checking and when specialists get more involved.

And, as Duncan said, if you’d ever like to talk it through with someone directly, our Support Services team is there, staffed by our brill nurses - you can call for free on 0808 2080 888 (option 1) or email support@bloodcancer.org.uk.

Take care,
Ceri - Blood Cancer UK Support Services

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Hi Ceri,

Thank you for your message.
I will be reviewed again in a consultant clinic on September 30 after another set of the usual blood tests. Shall post afterwards.

Do you know if this a usual occurrence on the Monoclonal gammopathy of unknown significance ('MGUS') pathway or a sign of something else?

Helen

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Hello @helenfwallace, thanks for your reply.

I am in no way a clinical expert at all, and only the Blood Cancer UK nurses are allowed to offer clinical advice on this forum, so I’m afraid I can’t comment as to that. It might be worth looking at this general page about MGUS, and contacting them about it - they might have more information.

I will also let you know if the Blood Cancer UK nurses have any comment, or they might reply here themselves.

And yes, please do let us know what is said on the 30th - and remember we are here in the interim, if you want to talk about the day to day lived experience of Monoclonal gammopathy of unknown significance ('MGUS').

Take care,

Ceri

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