MGUS with rising Free Lambda and falling kappa lambda ratio

General chat
1

I was diagnosed with Monoclonal gammopathy of unknown significance (MGUS), 4, years ago and apart from a couple of blips have been fairly stable. My paraprotein level has remained at 2. However I noticed my Free Lambda light chain has been rising, in May it was 116.6 (should be 10.3 - 24.4) then in July 123.4, with a kappa lambda ratio of 0.15, (normal is 0.99 - 1.8) I wondered if anyone had this? I watched a YouTube video that talked about light chains and suggested that a rising Lambda free chain and an abnormal kappa / lambda ratio could be a sign of Amyloidosis. I’m due a blood tests every next next month and will raise this with my haematologist if it goes up again. Has anyone experienced this? My Kappa free light chain is normal.

2 Likes
2

Hello @Hussyhemlock

Thank you for your post.

We are sorry to hear about your diagnosis of Monoclonal gammopathy of unknown significance (MGUS).

We are unable to comment on specific blood tests however, we would advise with any health worry or concern to contact your team/ GP who monitor your Monoclonal gammopathy of unknown significance (MGUS) for you and tell them about how you are feeling. It might be a good idea to tell them you are worried about Amyloidosis, so that this could be something they can then rule in or out as it may not be at the forefront of their mind.

It sounds reassuring that you have an appt next month and can raise this issue, but if it is playing on your mind, perhaps you have a clinical nurse specialist you can contact in the meantime?

We do have a page on What is MGUS | Blood Cancer UK which has a section that talks about types of Monoclonal gammopathy of unknown significance (MGUS) and may be useful for when you speak with your team.

For further information about Monoclonal gammopathy of unknown significance (Monoclonal gammopathy of unknown significance (MGUS)) our colleagues at Myeloma UK have a useful info sheet that may be helpful to read over MGUS Infosheet.

Take care & warm wishes,

Emma (support services nurse)

3 Likes
3

Thank you, I feel I can wait until next month, this forum is always so reassuring.

3 Likes