I’m wondering if anyone can put my mind at rest, I was diagnosed with Monoclonal gammopathy of unknown significance (MGUS) last year igm lambda low level at 1.17. I’ve just had my bloods, still waiting on paraprotein to see if changed as they forgot so had bloods again today. However this time my serum free light chains have come back Kappa 34.1 above high ref Lambda 13.6 and ratio 2.510 above high ref. I know the igm is low level and if changes, igm more likely to be Waldenström macroglobulinaemia (WM) or other lymph disorder but my question is how do I have igm lambda and high kappa light chains? Is this normal? My gp doesn’t understand and her reply from haematology said to wait six months could be due to inflammation?! Google says this shouldn’t happen it would be lambda light chains or this could be biclonal gammopathy - rare - which has further risks and to see haematologist. Has anyone had results like this? Any help would be great please?
Thank you for your reply, I understand Monoclonal gammopathy of unknown significance (MGUS) but this is the anomaly, I am igm lambda, and now have high kappa light chains. It seems I may have 2 types of Monoclonal gammopathy of unknown significance (MGUS) at the same time, biclonal igm lambda Monoclonal gammopathy of unknown significance (MGUS) and light chain Monoclonal gammopathy of unknown significance (MGUS).
I have biclonal myeloma I have 2 IGG proteins one sits at less than 2 the other is zero both are monitored I also have kappa light chains. Mine is secondary IGG after having two stem cell transplants.
My understanding is you have 2 abnormal IGM proteins along with kappa light chains Monoclonal gammopathy of unknown significance (MGUS)
Here’s AI version
Biclonal Monoclonal gammopathy of unknown significance (MGUS) (BGUS) is a rare condition where a patient has two distinct types of abnormal monoclonal proteins in their blood, rather than the single one seen in typical Monoclonal gammopathy of unknown significance (MGUS)
This AI for two Monoclonal gammopathy of unknown significance (MGUS)
No, a person cannot have two Monoclonal gammopathy of unknown significance (MGUS) (Monoclonal Gammopathy of Undetermined Significance) diagnoses at the same time because Monoclonal gammopathy of unknown significance (MGUS) is characterized by having only one type of abnormal protein. However, a person can have a biclonal gammopathy, which is a related condition where two distinct M-proteins are detected, or they could develop a second, different Monoclonal gammopathy of unknown significance (MGUS) at a later date, a condition known as secondary Monoclonal gammopathy of unknown significance (MGUS)
