I opted tonstart Pegasus early this year with mt Haemotologist. Started on 45mcg weekly which caused my neutrophils to drop below 0.5 whilst not controlling my HCT.
I had a 6 week break then back on same. Neutrophils again dropped. This time Haemo said have a 3 week break an if Neutrophils above 1 go to 3 weekly. Looks like this is working and its controlling my HCT.
I know we are all different but don’t give up at the first hurdle. The fight can make a difference.
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Oh @DougyW you have made my day, what a wonderful uplifting post.
Please do look after yourself and keep posing and perhaps a celebration is in order
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That’s great news @DougyW
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Thanks for sharing this @DougyW, fellow Polycythaemia vera (PV) survivor.
Sorry to have missed until now your very helpful posts around the forum about deciding on which cytoreductive medicine to take. I’m so glad yours is working so well! It gives me hope that if the hydroxyurea I take stops doing its job then there are other options 
Never thought I’d be singing the praises of chemotherapy but here we are!
Hope you stay well, long may treatments work!
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I think we stand on the verge of a change in approach of treatment of the Myeloproliferative neoplasms (MPN) family. There appears to be a growing weight of evidence that treating the genetic anomaly will stop the disease development if not reverse it. It may not be Pegasus we use but I firmly believe that will be the approach.
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I’ve been reading good things about this too @DougyW, especially in regards to CRISPR gene editing. Gives me hope that maybe remission could be possible for Myeloproliferative neoplasms (MPN) and other blood cancers, let alone curing them altogether.
The idea that I could reverse my pesky JAK2 mutation is pretty incredible, especially seeing as I only found out about blood cancers such as ours last year!
For now though I’ll keep my fingers crossed that our current treatments keep working and our cancers don’t transform, the little buggers!
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