What is CAR-T therapy?

CAR-T therapy is a new type of cancer treatment that uses the immune system to kill cancer cells. In some cases it has cured people where all other treatments have failed.

But what is it? How does it work? Who is eligible to receive it? Find out here :arrow_down:

Have you received it? Is it something you may need in the future? Do you have further questions about this treatment?

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I had CAR-T therapy last year. One of the complications that appeared after my SCT for a severe Aplastic Anaemia was Lymphoma. Attempts to curb it with R-Chop Chemo knocked out my new stem cell’s progress so I was put forward for CAR-T at Hammersmith Hospital. 1.2 billion cells were transfused over a 4 week period and a few months later a PET scan showed the tumour had halved, another 3 months later it had gone. This is an amazing treatment, without, for me at least, the unpleasant side effects of Chemo.


Thanks, Dawn, this is really interesting and informative, thanks.

Hi Fozzie, great to hear from you again, it is really useful to hear from someone who has actually had CAT-T therapy, take care and anything else you can tell us about your experiences would be helpful.

Hi, I have refractory aggressive DLBC. I am waiting on a PET scan and results to see if I can proceed with having CAR-T therapy, as this now seems to be my only option for remission. Is anyone else going to have this or had this treatment? I have been through a lot the last couple of years with the return of the disease and chemotherapy treatments. I am apprehensive about CAR-T and would like to hear about the experience of others.


Hi @Sara a great big welcome to our forum, I hope you find it supportive. We are here for you even if we cannot answer your question (I hope others will be able to) and you can contact the wonderful Blood Cancer UK Support Services Team on 0808 2080 888 10am-7pm Monday-Friday and 10am to 1pm Saturday and Sunday or via email at support@bloodcancer.org.uk to talk to someone. You seem to have been through a lot over the last couple of years and I expect the fears, thoughts and feelings you might have had, and are having, are shared by many of us. Please keep letting us know what it is like to be you.

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Hello @Sara a really warm welcome to the forum to you. I’m so sorry you’re going through what sounds like a really tough time. It’s totally understandable that you’re keen to hear from others who have experienced CAR-T and I hope you get a response from someone who has been through this treatment pathway. It sounds like you’ve been through an awful lot Sara, may I ask how you’re coping? Do you have much support around you?

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Hi Sara. I had CAR-T in spring 2018 for DLBC, which appeared a few months after my stem cell transplant. It was painless and quick to administer. The cells were transfused over four weeks. Each week was about 300,000,000 cells and the whole procedure was over pretty quickly. Over the 4 weeks I was given 1.2 billion cells and they completely destroyed the tumour in my colon in about 7 or 8 months, without the horrible side effects I had experienced after chemo and radiotherapy. I hesitate to say there is nothing to worry about, and appreciate that everyone is different and reacts differently to treatments, but I personally found it one of the easiest of the many treatments I had over a period of about 18 months when ill. Good luck with whatever treatment you have. Paul.