I have recently had urine tests which showed Monoclonal protein immunotyped as Free Kappa and Bence Jones protein which were followed up with bloods which were found to be abnormal as listed below so I’ve been referred on a cancer pathway to haematology and they rang me today 1 hr after receiving the referral which is brilliant but also worrying and I’m seeing haematology next Wednesday. My bloods were as follows
SERUM FREE LIGHT CHAINS
Serum kappa light chain level 90.15 mg/L [11.3 - 27.6]; Above high reference limit
Serum lambda light chain level 9.47 mg/L [10.3 - 24.4]; Below low reference limit
Serum kappa:lambda light chain ratio 9.52 ratio [0.99 - 1.8]; Above high reference limit
Monoclonal protein immunotyped as IgG Kappa
Serum protein electrophoresis
Immunoglobulin G level 9.14 g/L [6.0 - 16.0]
Immunoglobulin A level 0.97 g/L [0.8 - 4.0]
Immunoglobulin M level 0.56 g/L [0.5 - 2.0]
Serum protein electrophoresis Monoclonal band/s in Gamma detected
SERUM PARAPROTEIN QUANTITATION
PARAPROTEIN LEVEL 1
Unable to quantify paraprotein due to high
background polyclonality
Can anyone shed any light on what this might mean and what tests come next with the hospital?
Thanks
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Hi @Katiep, welcome to the Forum, though I’m sorry about the worries that bring you here.
The gap between getting test results and seeing a specialist is often difficult, and it’s understandable that it feels unsettling even as you recognise the speed is a positive thing in some ways.
I’m going to tag our Blood Cancer UK nurses - @BloodCancerUK_Nurses - because the questions you’re asking about what these markers might indicate, and what investigations are likely to follow, really need someone with clinical knowledge to answer properly. They’re much better placed than I am to give you any useful context, though of course they won’t be able to speak to your specific case in as much detail as your own healthcare specialists will.
What I can say is that your Wednesday appointment is the most important next step right now, and your haematology team will be able to explain your results and what they’re looking for in detail. It might be worth writing your questions down before you go, including the ones you’ve raised here, so nothing gets lost in the moment.
Our Support Line (which is staffed by the wonderful nurses) is there if you need someone to talk to before then: 0808 2080 888 (option 1) or support@bloodcancer.org.uk.
Do let us know how you get on, and take care,
Ceri - Blood Cancer UK Support Services
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Hello @Katiep
Welcome to our forum and thank you for your post.
We are sorry to hear that you are going through an understandably worrying time and please know that if you would like to talk through any of this with one of our support services nurses you can get in touch on 0808 2080 888.
We are unable to give individualised medical advice, but would recommend speaking to your GP or if you have a contact for the haematology team to see if they can give you further information about what they are looking at as a potential diagnosis. Have they said to you what this could be?
It sounds reassuring that the team are completing the relevant diagnostic tests. At upcoming appointments it is likely that the team will carry out further blood tests to compare with these ones that you have had taken and may want to organise a scan to have a look at your bones, this may involve an x-ray, PET or CT scan. You can find out more information about diagnostic tests on our page Blood cancer tests | Blood Cancer UK.
Paraprotein being present in blood samples does need investigating further, as it shouldn’t be there. There are a couple of possibilities for abnormal paraprotein readings; myeloma is one cause; there is also another blood cancer called Waldenstrom’s Globulinaemia (Waldenström macroglobulinaemia ('WM')) or a precancerous condition called Monoclonal gammopathy of unknown significance ('MGUS') (Monoclonal Gammopathy of Undetermined Significance). A haematologist would be the best person to look at all your blood results, investigate further and let you know what they think is causing the rise in paraprotein levels.
We don’t want to worry you further as your haematologist is best place to discuss a potential diagnosis but you may find our page Myeloma tests | Blood Cancer UK and MGUS – Myeloma Infosheet helpful to read over as they include useful information about diagnostic tests, further information about paraproteins and serum free light chains and may help when thinking of questions you’d like to ask the team.
You may also want to update them on any symptoms that you are having, but do let them know in the meantime if you feel that any of these are getting worse.
Do let us know how your appointment goes.
Take care & warm wishes,
Emma (support services nurse)
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Thank you for your response 
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